Hormone treatment with clomiphene

As clomiphene affects what is observed and in which cases it can help to baby happiness? The answers at a glance.

What is Clomiphene and how does it work?

At about one-third of women with fertility hormone balance is disturbed. This has often result in the maturation of oocytes is not working properly. Ovulation does not occur. A drug that is commonly used fertility treatment in the first step is clomiphene.

If ovulation fails, medications can help, such as clomiphene. (Photo: Thinkstock)

If ovulation fails, medications can help, such as clomiphene.

© iStock

Clomiphene is a drug that has an anti-estrogen. What sounds absurd at first glance, because estrogens significantly affect oocyte maturation in the female cycle works like this: Clomiphene deceives the body that too little estrogen are present. The pituitary gland tries this lack by increased production of follicle-stimulating (FSH) and luteinisierendenHormon (LH) to compensate. It is these hormones stimulate the ovarian function and ensure the maturation of ovarian follicles and ovulation.

Such as treatment with clomiphene work?

Clomiphene is often used because it has relatively few side effects and is easily taken in tablet form. Hormone replacement therapy begins at 3 to 5 days after the onset of menstruation. The following five days takes place the clomiphene-income daily. If the Einahme completed, ovulation usually takes place after about one week. Remains even after max. 20 days after taking stop ovulation from the treatment in the next cycle is repeated. During treatment, the follicular development is controlled (from the 8th day of the cycle) by the gynecologist with ultrasound. In order to control the hormone balance, is additionally bled at each cycle.

The cycle in brief

  • 1/7

    day 1

    Day 1 of the period is always also the start of a new cycle. The bleeding lasts 3-7 days, during which the top layer of the endometrium is shed.

  • 2/7

    FSH & estrogen

    The pituitary gland produces the hormone FSH (follicle stimulating hormone), it stimulates the follicles (follicles). They grow and produce estrogen. At the beginning of the cycle the estrogen level is relatively low, the closer the ovulation approaches, the more estrogen circulating in the body.

  • 3/7

    Best conditions

    Estrogen also causes the uterine lining thickens and has better circulation so that a fertilized egg in the worst case finds optimal conditions for implantation.

  • 4/7

    ovulation

    The rising estrogen levels results in Hinanhangdrüse to secretion of the hormone LH (luteinizing hormone). This hormone causes the mature follicle to release the egg, ovulation takes place.

  • 5/7

    Waiting for fertilization

    The egg travels through the fallopian tube to the uterus, about 24 hours it is viable and can be fertilized.

  • 6/7

    progesterone

    The follicle begins immediately after ovulation with the production of Progestoron. This hormone supports the further development of the uterine lining.

  • 7/7

    Hormone level drops

    If the egg is not fertilized, shrinks follicles and forms no hormones. The result: estrogen and progesterone levels drop, which thereby begins supported Gebörtmutterschleimhaut to peel off. The period begins.

Not always, treatment with clomiphene strikes immediately, because every body is ticking a little differently. As a rule, a maximum of 6 cycles treated with clomiphene, it does not work in the period, it is better to try a different treatment strategy.
What are the side effects?

It may be caused by Clomiphene to typical menopausal symptoms such. As hot flashes, headaches and mood swings. Rarely occurs a so-called hyperstimulation syndrome: in the ovaries too many and too large follicles are formed, which can lead to cyst formation. Furthermore, the risk of multiple pregnancy is increased in case of fertilization.


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